Hydrochloric Acid → HCID 57907537, compound

HRID 243667Notes

Reaction equation

HRID 243667 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH:14]([CH2:20][CH2:21][F:22])[C:15]([O:17]CC)=[O:16])[N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Li+].Cl>C1COCC1.CO>[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH:14]([CH2:20][CH2:21][F:22])[C:15]([OH:17])=[O:16])[N:13]=1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 57907450HCID 57907450, compound

Product 1

HCID 57907537HCID 57907537, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the product from step B (100 mg, 0.3 mmol) in a mixture of THF (1 mL) and methanol (0.3 mL) was added a solution of lithium hydroxide (0.3 mL of a 1 M soln, 0.3 mmol) and the resulting mixture stirred at room temperature for 90 min. 1N HCl (0.3 mL, 0.3 mmol) was added and the mixture evaporated to dryness. The resulting crude product was used immediately without purification.

Workup

  1. customthe mixture evaporated to dryness
  2. customThe resulting crude product was used immediately without purification

Sources & evidence

ORD record
ord-84c2750aa6f345798988fb987eb925b2
Source dataset
uspto-grants-2014_02
Patent number
US08653260B2

Reaction notes

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