反应详情

To a stirred solution of 1.0 g (6.9 mmol) of (2-oxo-1,3-oxazolidin-3-yl)acetic acid in 10 mL of anhydrous DMF was added 1.0 g (7.6 mmol) of potassium carbonate followed by 1.0 mL (8.3 mmol) of benzyl bromide. The reaction mixture was stirred for 3 h then quenched with water. The aqueous phase was extracted with ethyl acetate (3×25 mL) and the combined organics were washed with water (2×10 mL), brine (10 mL), dried over magnesium sulfate, filtered and evaporated in vacuo. The crude residue was purified by silica gel chromatography eluting with 50% ethyl acetate in hexanes to afford the title compound as a white solid 0.50 g (31%). LC-MS: m/z (ES) 236 (MH)+.

1. customthen quenched with water
2. extractionThe aqueous phase was extracted with ethyl acetate (3×25 mL)
3. washthe combined organics were washed with water (2×10 mL), brine (10 mL)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customevaporated in vacuo
7. customThe crude residue was purified by silica gel chromatography
8. washeluting with 50% ethyl acetate in hexanes