反应详情

285 mg (0.8 mmol) of (Z)-3-[1-(4-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone and 330 mg (4 mmol) of dimethylamine-hydrochloride are dissolved in 8 ml of DMF and after the addition of 385 mg (1.2 mmol) of TBTU, 184 mg (1.2 mmol) of HOBt and 1.03 g (8 mmol) of N-ethyl-N,N-diisopropylamine, the mixture is stirred for 14 hours at ambient temperature. The solution is diluted with water, the product precipitated is suction filtered, washed with water and ethanol and dried.

1. customthe product precipitated
2. filtrationfiltered
3. washwashed with water and ethanol
4. customdried