1-Hydroxybenzotriazole → HCID 178485470, compound

HRID 24749Notes

Reaction equation

HRID 24749 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10]/[C:11](=[C:18]2\[C:19](=[O:27])[NH:20][C:21]3[C:26]\2=[CH:25][CH:24]=[CH:23][CH:22]=3)/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:6][CH:5]=1)([OH:3])=O.Cl.CN.[CH3:31][N:32](C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1.C(N(C(C)C)C(C)C)C>CN(C=O)C>[CH3:31][NH:32][C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10]/[C:11](=[C:18]2\[C:19](=[O:27])[NH:20][C:21]3[C:26]\2=[CH:25][CH:24]=[CH:23][CH:22]=3)/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:8][CH:9]=1)=[O:3]

Participants

7

Reactant 5

HCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 6364545Methylamine hydrochlorideHCID 1785170884-[[(Z)-(2-oxo-1H-indol-3-ylidene)-phenylmethyl]amino]benzoic acid

Product 1

HCID 178485470HCID 178485470, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 18 from (Z)-3-[1-(4-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone, methylamine-hydrochloride, TBTU, HOBt and N-ethyl-N,N-diisopropylamine in DMF.

Sources & evidence

ORD record
ord-e3ae603ae8a94acf81fde332878092f2
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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