Hydrochloric Acid → HCID 178422345, compound

HRID 248426Notes

Reaction equation

HRID 248426 reaction equation
[CH3:1][C:2]1[CH:16]=[C:5]2[N:6](C(=O)C)[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:4]2[N:3]=1.Cl.C(=O)(O)[O-].[Na+]>C(O)C.O>[CH3:1][C:2]1[CH:16]=[C:5]2[NH:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:4]2[N:3]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 12463541HCID 12463541, compound

Product 1

HCID 178422345HCID 178422345, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

2-Methyl-4-acetylpyrazolo[1,5-a]benzimidazole (11), (0.25 g, 1.17 mmol), was added to a mixture of concentrated hydrochloric acid (0.5 ml) in ethanol (5 ml) and heated to reflux for 20 minutes. The solution was cooled to room temperature and poured into a solution of sodium bicarbonate in water (30 ml) to afford a light tan solid which was filtered off, washed and dried, mp. 248°-252° C., 0.20 g, 99%. This was shown by comparative thin layer chromatography and infra-red analysis to be identical to an authentic sample of 2-methylpyrazolo-[1,5-a]benzimidazole (6).

Workup

  1. temperatureheated
  2. temperatureto reflux for 20 minutes
  3. customto afford a light tan solid which
  4. filtrationwas filtered off
  5. washwashed
  6. customdried

Sources & evidence

ORD record
ord-c5b86df41bb24ec8b91df6d84d8e5248
Source dataset
uspto-grants-1993_05
Patent number
US05210209

Reaction notes

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