Chloroform → HCID 131717905, compound

HRID 248536Notes

Reaction equation

HRID 248536 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:26])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH:16]([C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=5)[CH2:15]4)[CH:12]=3)[C:7](=[O:27])[C:6]([C:28]([OH:30])=[O:29])=[CH:5]2)[CH2:3][CH2:2]1.C(Cl)(Cl)[Cl:32].CN(C)C=O>C(O)C.Cl>[ClH:32].[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:26])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH:16]([C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=5)[CH2:15]4)[CH:12]=3)[C:7](=[O:27])[C:6]([C:28]([OH:30])=[O:29])=[CH:5]2)[CH2:2][CH2:3]1

Participants

6

Reactant 3

HCID 6212ChloroformHCID 6228DimethylformamideHCID 23042966HCID 23042966, compound

Product 1

HCID 131717905HCID 131717905, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 702EthanolSolvent

Procedure

A 54 mg portion of the base compound from Example 128 was dissolved, with heat, in a mixture of ethanol, chloroform and a little dimethylformamide. A few drops of concentrated hydrochloric acid were added, the solid was collected, washed with water, ether and dried, giving 35 mg of the desired product.

Workup

  1. customthe solid was collected
  2. washwashed with water, ether
  3. customdried

Sources & evidence

ORD record
ord-e7ea54ae83e0496f99beb7c0cc5ad309
Source dataset
uspto-grants-1993_05
Patent number
US05210193

Reaction notes

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