Lithium hydroxide, monohydrate → HCID 66874178, compound

HRID 249849Notes

Reaction equation

HRID 249849 reaction equation
Cl[C:2]1[O:3][C:4]2[C:5](=[C:7]([C:11]([O:13]C)=[O:12])[CH:8]=[CH:9][CH:10]=2)[N:6]=1.[OH2:15].[OH-].[Li+:17]>C1COCC1.O>[O:15]=[C:2]1[NH:6][C:5]2=[C:7]([C:11]([O-:13])=[O:12])[CH:8]=[CH:9][CH:10]=[C:4]2[O:3]1.[Li+:17]

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 56924368Methyl 2-chlorobenzo[d]oxazole-4-carboxylate

Product 1

HCID 66874178HCID 66874178, compoundYield 149.5%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 2-chlorobenzoxazole-4-carboxylate (100 mg, 0.47 mmol) in THF (6 mL) was added a solution of lithium hydroxide monohydrate (29.7 mg, 0.71 mmol) in H2O (3 mL). The reaction mixture was stirred at room temperature for 18 h and then concentrated to dryness to afford lithium 2-oxo-2,3-dihydrobenzoxazole-4-carboxylate (130 mg, 100%) as a yellow solid that was directly used in the next step without purification. MS consistent

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-a4a25d5f4e6449f5bca886f62ee8d3b3
Source dataset
uspto-grants-2011_01
Patent number
US07863271B2

Reaction notes

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