Water → Ethyl 4-(isopropylamino)-7-[3-(methylsulphanyl)propoxy]quinazoline-6-carboxylate

HRID 249985Notes

Reaction equation

HRID 249985 reaction equation
[H-].[Na+].[OH:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([NH:14][CH:15]([CH3:17])[CH3:16])=[N:9][CH:10]=[N:11]2)=[CH:6][C:5]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19].[CH3:23][S:24][CH2:25][CH2:26][CH2:27]OS(C1C=CC(C)=CC=1)(=O)=O.O>CN(C)C=O.C(OCC)(=O)C>[CH:15]([NH:14][C:8]1[C:7]2[C:12](=[CH:13][C:4]([O:3][CH2:27][CH2:26][CH2:25][S:24][CH3:23])=[C:5]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:6]=2)[N:11]=[CH:10][N:9]=1)([CH3:17])[CH3:16]

Participants

7

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 153109983-(Methylthio)propyl 4-methylbenzenesulfonateHCID 136101838Ethyl 7-hydroxy-4-(isopropylamino)quinazoline-6-carboxylate

Product 1

HCID 57787956Ethyl 4-(isopropylamino)-7-[3-(methylsulphanyl)propoxy]quinazoline-6-carboxylateYield 48%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

Sodium hydride (60%, 251 mg, 6.3 mmol) is introduced into N,N-dimethylformamide (13 ml), treated in portions with ethyl 7-hydroxy-4-(isopropylamino)quinazoline-6-carboxylate (1 g, 2.98 mmol) and subsequently stirred at room temperature for 30 minutes. After addition of a solution of 3-(methylthio)-1-(tosyloxy)propane (777 mg, 2.98 mmol) in N,N-dimethylformamide (8 ml), the mixture is stirred at 80° C. for one hour. After cooling, the batch is treated with water and ethyl acetate, and the organic phase is separated off and dried over sodium sulphate. The desired product is obtained after removing the solvents and preparative HPLC in 48% yield (548 mg).

Workup

  1. stirringthe mixture is stirred at 80° C. for one hour
  2. temperatureAfter cooling
  3. customthe organic phase is separated off
  4. dry with materialdried over sodium sulphate

Sources & evidence

ORD record
ord-81f41fae9f5d4001ba50ceac479e75d0
Source dataset
uspto-grants-2011_01
Patent number
US07863283B2

Reaction notes

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