反应详情

温度

70 °C

A mixture of 1.00 g (2.50 mmol) of the starting material XVIII, 20 ml of dimethylformamide and 0.94 g (6.14 mmol) of methyl bromoacetate was stirred at 70° C. for 1.5 h. After dilution with water the precipitated crystals were filtered off and purified by refluxing in ethyl acetate to yield 0.41 g (37%) of the title compound; Mp.: 294-295° C. (dec.).

1. filtrationAfter dilution with water the precipitated crystals were filtered off
2. custompurified
3. temperatureby refluxing in ethyl acetate