反应详情

A mixture of 4-(3-chloropropoxy)benzoate ax13 (2.01 g, 8.79 mmol, 1 eq), potassium carbonate (2.43 g, 17.6 mmol, 2 eq), sodium iodide (catalytic amount) and piperidine (1 ml, 9.67 mmol, 1.1 eq) in acetonitrile (100 ml) is stirred at reflux for 56 h. The solvent is removed under vacuum and the solid is triturated in hexane and filtered. The resulting solution is concentrated to give methyl 4-(3-piperidin-1-ylpropoxy)benzoate ax15 as a yellow oil (2.2 g).

1. temperatureat reflux for 56 h
2. customThe solvent is removed under vacuum
3. customthe solid is triturated in hexane
4. filtrationfiltered
5. concentrationThe resulting solution is concentrated