Hydrazine hydrate (1:1) → HCID 67268872, compound

HRID 251746Notes

Reaction equation

HRID 251746 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([C:13]([O:15]C)=O)[CH:4]=1.O.[NH2:18][NH2:19]>CC(O)C>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([C:13]([NH:18][NH2:19])=[O:15])[CH:4]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 523521HCID 523521, compound

Product 1

HCID 67268872HCID 67268872, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
80 °C

Procedure

The methyl 4-methoxyquinoline-2-carboxylate (1 eq) was dissolved in i-PrOH (0.75 M) and then hydrazine monohydrate (10 eq) was added. The reaction mixture was heated at 80° C. overnight and then the solvent was evaporated under reduced pressure and the crude product was used in the next step without purification. MS (ES) C11H11N3O2 required: 217, found: 218 (M+H)+.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customthe crude product was used in the next step without purification

Sources & evidence

ORD record
ord-65f1e5d6e90e4349a414f7bd46654e23
Source dataset
uspto-grants-2011_01
Patent number
US07863294B2

Reaction notes

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