Hydrochloric Acid → 3-Pyridinecarboxylic acid, 6-(4-amino-1-piperidinyl)-, ethyl ester

HRID 25235Notes

Reaction equation

HRID 25235 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:17][N:16]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.Cl>C(OCC)(=O)C>[NH2:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:17][N:16]=2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 225744464-Tert-butoxycarbonylamino-1-(5-ethoxycarbonyl-pyrid-2-yl) piperidine

Product 1

HCID 114024293-Pyridinecarboxylic acid, 6-(4-amino-1-piperidinyl)-, ethyl ester

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

The product of stage b) is dissolved in ethyl acetate, a 3N solution of hydrochloric acid in ethyl acetate is added and the mixture is left stirring at ambient temperature for 10 hours. The product is filtered off and washed with acetone. The title product is obtained. M.p.: 148-150° C.

Workup

  1. waitthe mixture is left
  2. filtrationThe product is filtered off
  3. washwashed with acetone

Sources & evidence

ORD record
ord-007fab9badaf4c7ca8c9d853d77769da
Source dataset
uspto-grants-2005_02
Patent number
US06858629B1

Reaction notes

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