反应详情

温度

-5 °C

A solution of aldehyde 80 (253 mg, 1.3 mmol) in tetrahydrofurane (1 mL) and propan-2-ol (2 mL) was treated with solid sodium borohydride (175 mg, 4.6 mmol) and stirred at −5° C. for 15 min. Acetone (5 mL) was added, stirred at the same temperature for 10 min and then diluted with ethyl acetate (100 mL), washed with 5% KHSO4 in water, then saturated NaHCO3 and finally with water, dried (MgSO4), and used for the next step without further purification.

1. stirringstirred at the same temperature for 10 min
2. washwashed with 5% KHSO4 in water
3. dry with materialsaturated NaHCO3 and finally with water, dried (MgSO4)
4. customused for the next step without further purification