Methanol → HCID 59736823, compound

HRID 252861Notes

Reaction equation

HRID 252861 reaction equation
[N+:1]([C:4]1[CH:17]=[C:16]([C:18]2[S:19][CH:20]=[CH:21][CH:22]=2)[CH:15]=[CH:14][C:5]=1[O:6][Si:7]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8])([O-])=O.CO>C(OCC)(=O)C.C(N(CC)CC)C>[NH2:1][C:4]1[CH:17]=[C:16]([C:18]2[S:19][CH:20]=[CH:21][CH:22]=2)[CH:15]=[CH:14][C:5]=1[O:6][Si:7]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8]

Participants

5

Reactant 2

HCID 887MethanolHCID 59736932HCID 59736932, compound

Product 1

HCID 59736823HCID 59736823, compoundYield 41%

Reagents, catalysts & solvents 2

HCID 8471TriethylamineSolventHCID 8857Ethyl AcetateSolvent

Procedure

Following the same procedure described for Example 48, step 3 (scheme 36) but substituting compound 171 for compound 299 and using ethyl acetate and triethylamine as a solvent instead methanol, the title compound 300 was obtained in 41% yield over two steps. MS: calc: 305.5; found: 306.1 (M+H).

Sources & evidence

ORD record
ord-0846b8df4f534f3f98e4eb71c173fb66
Source dataset
uspto-grants-2011_01
Patent number
US07868205B2

Reaction notes

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