反应详情

A solution of 2-amino-6-(2-furyl)pyrimidine-4-carboxylic acid (103 mg, 0.5 mmol) in DMF (2 mL) was treated with benzylamine (59 mg, 0.55 mmol), EDCl (104 mg, 0.54 mmol) and 4-dimethylaminopyridine (66 mg, 0.54 mmol), stirred at room temperature for 17 h, poured into water (25 mL) and extracted with EtOAc (2×25 mL). The combined organic phase was washed with water (25 mL), dried (MgSO4), concentrated in vacuo and purified by chromatography [SiO2; isopropyl ether:EtOAc, (100:0-0:100)] to give the title compound (52 mg, 40%) as an off-white solid.

1. extractionextracted with EtOAc (2×25 mL)
2. washThe combined organic phase was washed with water (25 mL)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo
5. custompurified by chromatography [SiO2; isopropyl ether:EtOAc, (100:0-0:100)]