Hydrochloric Acid → HCID 66852303, compound

HRID 254192Notes

Reaction equation

HRID 254192 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[C:20]3[C:15](=[CH:16][C:17]([N+:21]([O-:23])=[O:22])=[CH:18][CH:19]=3)[C:14]([CH2:24][N:25]3[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]3)=[CH:13]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[ClH:32]>C(O)(C)C>[ClH:32].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([N:12]2[C:20]3[C:15](=[CH:16][C:17]([N+:21]([O-:23])=[O:22])=[CH:18][CH:19]=3)[C:14]([CH2:24][N:25]3[CH2:26][CH2:27][N:28]([CH3:31])[CH2:29][CH2:30]3)=[CH:13]2)(=[O:10])=[O:11])=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10343421HCID 10343421, compound

Product 1

HCID 66852303HCID 66852303, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a 4.45 g of 1-(4-Methoxybenzenesulfonyl)-3-(4-methylpiperazin-1-ylmethyl)-5-nitro-1H-indole (example-124), was added the saturated solution of hydrochloric acid in isopropyl alcohol and stirred at room temperature till crystalline compound separates out. The compound was isolated by filtration, washed with n-hexane, ethylacetate and dried under vacuum. IR spectra (cm−1): 1159, 1263, 1337, 1372; Mass (m/z): 445 M+H)+

Workup

  1. customThe compound was isolated by filtration
  2. washwashed with n-hexane, ethylacetate
  3. customdried under vacuum

Sources & evidence

ORD record
ord-9ae6ac8ae95549a78ec15c2565bbb820
Source dataset
uspto-grants-2011_01
Patent number
US07875605B2

Reaction notes

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