反应详情

温度

155 °C

A mixture of 4-[(4-fluorobenzyl)oxy]pyridin-2(1H)-one (1.10 g, 5.0 mmol), (2E)-3-(4-bromophenyl)-2-propen-1-ol (1.28 g, 6 mmol), cuprous iodide (476 mg, 3 mmol), potassium carbonate (829 mg, 6 mmol) and DMF (20 mL) was stirred overnight at 155° C. The reaction liquid was cooled to room temperature, then poured into ammonia water, and ethyl acetate was added for extraction. The organic layer was washed with water and saturated saline, and dried with anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure, followed by purification by flash column chromatography (KP-Sil, hexane:ethyl acetate=1:1 to 0:1) to obtain the entitled compound (881 mg).

1. customThe reaction liquid
2. temperaturewas cooled to room temperature
3. additionwas added for extraction
4. washThe organic layer was washed with water and saturated saline
5. dry with materialdried with anhydrous magnesium sulfate
6. concentrationThe solvent was concentrated under reduced pressure
7. customfollowed by purification by flash column chromatography (KP-Sil, hexane:ethyl acetate=1:1 to 0:1)