Trifluoroacetic acid → HCID 58951740, compound

HRID 254605Notes

Reaction equation

HRID 254605 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[CH:9]=1)O.C([SiH](CC)CC)C.FC(F)(F)C(O)=O>>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][C:8]1[CH:9]=[C:10]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 58951705HCID 58951705, compound

Product 1

HCID 58951740HCID 58951740, compound

Procedure

4-[3-(1H-Imidazol-2-ylmethyl)-phenyl]-pyridine was prepared from rac-(1H-imidazol-2-yl)-(3-pyridin-4-yl-phenyl)-methanol, triethylsilane and trifluoroacetic acid in analogy to Example 191e): white crystals; MS (ISP): 236.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-77ee5b67ddff482cab57aa797c9c4a81
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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