Citric Acid → HCID 86602716, compound

HRID 254615Notes

Reaction equation

HRID 254615 reaction equation
NC(CO)(CO)CO.C(N(CCO)CCO)CO.[CH2:19]([C:23](O)(C(O)=O)[CH2:24][C:25]([OH:27])=[O:26])[C:20](O)=O.[OH-].[Na+].Cl.[OH:35][C:36]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])=[O:37]>O>[OH:37][C:36]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])=[O:35].[C:25]([OH:27])(=[O:26])[CH2:24][CH2:23][CH2:19][CH2:20][CH2:36][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43]

Participants

8

Reactant 6

HCID 311Citric AcidHCID 313Hydrochloric Acid2×HCID 2969Decanoic Acid2×HCID 6503Tris(hydroxymethyl)aminomethaneHCID 7618TriethanolamineHCID 14798Sodium Hydroxide3×

Product 1

HCID 86602716HCID 86602716, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

We transferred approximately 60% of the required sterile water volume into a suitable container. We added the appropriate amount (as indicated in the table below) of tromethamine, trolamine, citric acid anhydrous, and sodium hydroxide pellets to the container and mixed well until dissolved. We adjusted the temperature to 21-25° C. (or room temperature) and measured the pH of the liquid. We adjusted the pH to 7.7-7.9 as necessary using 1N sodium hydroxide or 1N hydrochloric acid. We then adjusted the temperature to 45-50° C. by warming on a hotplate and maintained this temperature. We then added the capric acid to the warm solution and mixed until the capric acid was dissolved. We adjusted the temperature to 21-25° C. (or room temperature) and measured the pH of the liquid. As needed, we adjusted the pH to 7.7-7.9 using 1N sodium hydroxide or 1N hydrochloric acid. We then mixed the solution for 5 minutes. We added appropriate amount of sterile water to equal 100% of the required volume and mixed well.

Workup

  1. additionWe added the appropriate amount (
  2. additionmixed well
  3. dissolutionuntil dissolved
  4. customto 21-25° C.
  5. custom(or room temperature)
  6. customto 45-50° C.
  7. temperatureby warming on a hotplate
  8. temperaturemaintained this temperature
  9. dissolutionwas dissolved
  10. customto 21-25° C.
  11. custom(or room temperature)
  12. additionWe then mixed the solution for 5 minutes
  13. additionmixed well

Sources & evidence

ORD record
ord-12aa63e483a6488f9ce6789442153e41
Source dataset
uspto-grants-2011_01
Patent number
US07875700B2

Reaction notes

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