反应详情

温度

80 °C

A mixture of 5-bromothiazol-2-amine (3.0 g, 11.5 mmol), adamantane-1-carbonyl chloride (2.74 g, 13.8 mmol), triethylamine (3.2 mL, 23 mmol) and 4-di(methylamino)pyridine (1.1 g) in tetrahydrofuran (100 mL) was heated at 80° C. for 48 hours. The mixture was cooled to ambient temperature, concentrated, diluted with water and extracted with ethyl acetate. The organic extract was dried (Na2SO4), filtered and concentrated. Purification by flash chromatography (silica gel, 25% ethyl acetate/hexanes) afforded the title compound, MS (ESI) m/z 342 (M+H)+

1. temperatureThe mixture was cooled to ambient temperature
2. concentrationconcentrated
3. additiondiluted with water
4. extractionextracted with ethyl acetate
5. extractionThe organic extract
6. dry with materialwas dried (Na2SO4)
7. filtrationfiltered
8. concentrationconcentrated
9. customPurification by flash chromatography (silica gel, 25% ethyl acetate/hexanes)