反应详情

A mixture of 4-phenyl-pyrrolidin-2-one (24.2 g; 0.15 mole) and sodium hydride (80% oil suspension)(5.4 g; 0.18 mole) in tetrahydrofuran (150 ml) is refluxed for 2.5 hrs. After cooling, ethyl iodide (29 g; 0.185 mole) is added thereto, and the resulting material is refluxed for another 5 hrs. The solvent is then evaporated off; the residue is taken up into chloroform, washed with water, dried and distilled. B.p.(0.2 mm Hg)=124°-126° C. Yield: 57%.

1. temperatureis refluxed for 2.5 hrs
2. temperatureAfter cooling
3. temperaturethe resulting material is refluxed for another 5 hrs
4. customThe solvent is then evaporated off
5. washwashed with water
6. customdried
7. distillationdistilled
8. custom(0.2 mm Hg)=124°-126° C