反应详情

To stirred suspension of 3.35 g of 50% sodium hydride and 10.92 g of benzyl bromide in 75 ml of dimethylformamide was added a solution of 19 g of 1-(hexadecyloxy)-3-buten-2-ol in 75 ml of dimethylformamide. The mixture was stirred overnight, then water was added and the mixture was extracted with ether. The ether extract was dried over magnesium sulfate and activated charcoal and the solvent removed giving an oil. This oil was purified by HPLC [hexane: chloroform (8:1)] and the solvent removed giving 12 g of the desired compound as an oil.

1. stirringThe mixture was stirred overnight
2. extractionthe mixture was extracted with ether
3. extractionThe ether extract
4. dry with materialwas dried over magnesium sulfate and activated charcoal
5. customthe solvent removed
6. customgiving an oil
7. customThis oil was purified by HPLC [hexane: chloroform (8:1)]
8. customthe solvent removed