反应详情

Anhydrous aluminum chloride (1.5 g) was added to N,N-dimethylformamide (20 ml) under ice cooling and the resulting mixture was stirred for fifteen minutes. To the mixture was added sodium azide (0.65 g), followed by a 15 minute-stirring, addition of 2-chlorophenylisocyanate (1.53 g) and heating at 70° to 75° C. for three hours, in that order. After cooling, the reaction mixture was added with stirring to a mixture of sodium nitrite (1 g), water (200 ml) and ice (100 g) and the resulting mixture was acidified was 10% hydrochloric acid (until a potassium iodide starch paper became discolored), followed by extraction with ethyl acetate. The thus obtained ethyl acetate layer was washed with water, dried over sodium sulfate and evaporated under reduced pressure. The resulting residue was purified by flash column chromatography (eluent: hexane:ethyl acetate = 2:1) to obtain the desired 1-(2-chlorophenyl)-5(4H)-tetrazolinone (1.8 g) having a m.p. in the range of from 124.5° C. to 125.5° C. in a yield of 92% of theory.

1. stirring-stirring
2. temperatureheating at 70° to 75° C. for three hours, in that order
3. temperatureAfter cooling
4. additionthe reaction mixture was added
5. extractionfollowed by extraction with ethyl acetate
6. washThe thus obtained ethyl acetate layer was washed with water
7. dry with materialdried over sodium sulfate
8. customevaporated under reduced pressure
9. customThe resulting residue was purified by flash column chromatography (eluent: hexane:ethyl acetate = 2:1)