反应详情

A solution of 1.03 g (0.011 mole) of 2-chloroacetamide in 8 ml of dimethylformamide was added dropwise to a stirred solution of 3.57 g (0.01 mole) of 10-hydroxy-5,5-dimethyl-8-(1,2-dimethylheptyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine in 12 ml of dimethylformamide and 1.11 g (0.011 mole) of triethylamine. After stirring for 17 hours, the mixture was diluted with 20 ml. of water and extracted with ether. The combined ether extracts were washed with water, dried over anhydrous sodium sulfate, and evaporated in vacuo. The residue was recrystallized from acetonitrile, m.p. 165°-168°.

1. additionthe mixture was diluted with 20 ml
2. extractionof water and extracted with ether
3. washThe combined ether extracts were washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated in vacuo
6. customThe residue was recrystallized from acetonitrile, m.p. 165°-168°