Hydrogen Sulfide → HCID 12526353, compound

HRID 262026Notes

Reaction equation

HRID 262026 reaction equation
[SH2:1].[CH3:2][S:3][C:4]1[S:5][C:6]([C:10]#[N:11])=[C:7]([NH2:9])[N:8]=1.C(N(CC)CC)C>CN(C)C=O>[CH3:2][S:3][C:4]1[S:5][C:6]([C:10](=[S:1])[NH2:11])=[C:7]([NH2:9])[N:8]=1

Participants

5

Reactant 3

HCID 402Hydrogen SulfideHCID 8471TriethylamineHCID 6764114-Amino-2-(methylsulfanyl)-1,3-thiazole-5-carbonitrile

Product 1

HCID 12526353HCID 12526353, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

20 parts of hydrogen sulfide are introduced, over 6 hours, into a mixture of 51.3 parts of 2-methylmercapto-4-amino-5-cyanothiazole, 0.2 part of triethylamine and 150 parts of dimethylformamide. The reaction mixture is left to stand for 48 hours and is then poured into 500 parts of ice water, and the product is filtered off. 33 parts of 2-methylmercapto-4-amino-5-thiocarbamoylthiazole (54% of theory) of melting point 192°-195° C. are obtained.

Workup

  1. waitThe reaction mixture is left
  2. filtrationthe product is filtered off

Sources & evidence

ORD record
ord-57a519576cd049aa94634a65d63f5110
Source dataset
uspto-grants-1979_05
Patent number
US04153607

Reaction notes

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