Hydrogen Sulfide → 2-Pyrrolidino-4-amino-5-thiocarbamoylthiazole

HRID 262031Notes

Reaction equation

HRID 262031 reaction equation
[N:1]1([C:6]2[S:7][C:8]([C:12]#[N:13])=[C:9]([NH2:11])[N:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[SH2:14].CN(C)C=O>C(N(CC)CC)C>[N:1]1([C:6]2[S:7][C:8]([C:12](=[S:14])[NH2:13])=[C:9]([NH2:11])[N:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 402Hydrogen SulfideHCID 6228DimethylformamideHCID 12526351HCID 12526351, compound

Product 1

HCID 125263542-Pyrrolidino-4-amino-5-thiocarbamoylthiazoleYield 53%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

25 parts of 2-pyrrolidino-4-amino-5-cyanothiazole are reacted with 8 parts of hydrogen sulfide in 150 parts of dimethylformamide and 2 parts of triethylamine, by the method described in Example 1(a). 15.6 parts of 2-pyrrolidino-4-amino-5-thiocarbamoyl-thiazole (53% of theory) of melting point 264°-265° C. are obtained.

Sources & evidence

ORD record
ord-c6df370ae3104f9796cc2fd91f1131c9
Source dataset
uspto-grants-1979_05
Patent number
US04153607

Reaction notes

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