Iodoethane → HCID 54549235, compound

HRID 262737Notes

Reaction equation

HRID 262737 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:23][CH2:22][C@@:13]34[C:14]5[CH:15]=[C:16]([OH:21])[CH:17]=[CH:18][C:19]=5[CH2:20][C@@H:7]2[C@@H:8]3[CH2:9][CH2:10][O:11][CH2:12]4)=[O:5])[CH2:3][CH2:2]1.[CH2:24](I)[CH3:25].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH:1]1([C:4]([N:6]2[CH2:23][CH2:22][C@@:13]34[C:14]5[CH:15]=[C:16]([O:21][CH2:24][CH3:25])[CH:17]=[CH:18][C:19]=5[CH2:20][C@@H:7]2[C@@H:8]3[CH2:9][CH2:10][O:11][CH2:12]4)=[O:5])[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 53687196HCID 53687196, compound

Product 1

HCID 54549235HCID 54549235, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of the product of Step (b) (XXXII) (0.005 m), ethyl iodide (0.006 m) and potassium carbonate (2 g) in 20 ml of acetonitrile is heated at reflux for 18 hours. The mixture is then filtered and the filtrate is concentrated. The residue is treated with water and extracted with ethyl acetate. The extracts are dried (Na2SO4) and concentrated to give the title product.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 18 hours
  3. filtrationThe mixture is then filtered
  4. concentrationthe filtrate is concentrated
  5. additionThe residue is treated with water
  6. extractionextracted with ethyl acetate
  7. dry with materialThe extracts are dried (Na2SO4)
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-86afa96786424ce38294b3a59cb94024
Source dataset
uspto-grants-1979_05
Patent number
US04154932

Reaction notes

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