反应详情

温度

-7 °C

To commercially available biphenyl (0.08 mole) and anhydrous aluminium trichloride (0.1 mole) dissolved in dry nitrobenzene (90ml), (+)-3-methylpentanoylchloride (0.1mole) the preparation of which is known and described in United Kingdom Patent Application No. 36211/75), is added in drops, the temperature being maintained at about -7° C. during the addition. The mixture is then stirred for about 18 hr. with cooling in an ice bath. It is then poured onto a mixture of ice, water and concentrated hydrochloric acid and stirred for 0.5 hr., and the nitrobenzene layer is separated. The nitrobenzene is removed by steam distillation and the residue is crystallised from a small volume of ethanol to constant melting point.

1. addition36211/75), is added in drops
2. temperaturewith cooling in an ice bath
3. stirringstirred for 0.5 hr
4. custom, and the nitrobenzene layer is separated
5. customThe nitrobenzene is removed by steam distillation
6. customthe residue is crystallised from a small volume of ethanol to constant melting point