反应详情

In a reactor, 10.0 g of 4-bromophenol, 7.95 g of ethylene bromohydrin, 16.0 g of K2CO3, and 300 ml of acetone were charged, and stirred and refluxed for 50 hours to give a reaction solution. The reaction solution was poured into water, extracted with toluene, washed with water, and thereafter dried over sodium sulfate anhydride, and the solvent was evaporated and the residue was distilled under reduced pressure in GTO (glass tube oven) to give 5.55 g (Y., 44.3%) of 1-bromo-4-(2-hydroxyethoxy)benzene. GC; 96.8% b.p.; 100° C./0.1 mmHg (which was the prescribed temperature of GTO)

1. temperaturerefluxed for 50 hours
2. customto give a reaction solution
3. extractionextracted with toluene
4. washwashed with water
5. dry with materialdried over sodium sulfate anhydride
6. customthe solvent was evaporated
7. distillationthe residue was distilled under reduced pressure in GTO (glass tube oven)