反应详情

4-Methylcyclohexanone (224 g, 2 moles) was added dropwise rapidly to a cooled, stirred suspension of 170 g (4 moles) of sodium amide in 2 l of tetrahydrofuran under nitrogen. After the addition was complete, the ice bath was removed and the mixture was heated at reflux until the evolution of ammonia ceased (~3 hours). While still at reflux, 142.5 g (1 mole) of o-chloroanisole was added rapidly dropwise and the mixture was heated for an additional hour, until evolution of ammonia ceased.

1. additionAfter the addition
2. customthe ice bath was removed
3. temperaturethe mixture was heated
4. temperatureat reflux until the evolution of ammonia
5. custom(~3 hours)
6. temperatureWhile still at reflux