Sodium hydride → Octimibate

HRID 265420Notes

Reaction equation

HRID 265420 reaction equation
[C:1]1([N:7]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:9]=[C:8]2Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34].[H-].[Na+]>CN(C)C=O>[C:1]1([N:7]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:9]=[C:8]2[O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 698208-Hydroxyoctanoic acidHCID 12675128HCID 12675128, compound

Product 1

HCID 65676Octimibate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1,4,5-Triphenyl-2-chloroimidazole was treated with 8-hydroxyoctanoic acid and sodium hydride in dimethylformamide to give the title compound, m.p. 158°-159° C., Found: C, 75.3; H, 6.6;N, 6.0%; C29H30N2O3.0.43H2O Requires: C, 75.3;H, 6.7; N, 6.0%

Sources & evidence

ORD record
ord-76ac360b82104bbaa4280a81906f62fd
Source dataset
uspto-grants-1997_07
Patent number
US05648373

Reaction notes

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