HRID26586

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID6422

未命名化合物

HCID7519

Anisole

C7H8O

2 次

HCID516892

Sodium Bicarbonate

CHNaO3

结构：CC(=O)OCC1=C(P(=O)(O)O)N2C(=O)[C@@H](NC(=O)C(C(=O)OC(c3ccccc3)c3ccccc3)c3ccccc3)[C@H]2SC1

HCID70606535

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCC1=C(P(=O)([O-])[O-])N2C(=O)[C@@H](NC(=O)C(C(=O)O)c3ccccc3)[C@H]2SC1.[Na+].[Na+].[Na+]

HCID131710825

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

One gram of 3-acetoxymethyl-7β-(2-phenyl-2-benzhydryloxycarbonylacetamido)-3-cephem-4-phosphonic acid is dissolved in 2 ml. anisole and treated for two minutes at 0° with 10 ml. trifluoroacetic acid. The mixture is pumped at 0.1 mm at 25° until most of the anisole is removed, and then more anisole is added and pumped off to insure complete removal of TFA. The residue is taken up in 100 ml. water containing three equivalents of NaHCO3, washed with methylene chloride and lyophilized, affording the product, trisodium 3-acetoxymethyl-7β-(2-carboxy-2-phenylacetamido)-3-cephem-4-phosphonate.

WORKUP

后处理

customis pumped at 0.1 mm at 25°
customis removed
additionmore anisole is added
customremoval of TFA

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a7e64c21a794da1bb823a937f6e27c3
来源数据集: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04150223
来源说明: uspto-grants-1979_04

反应 SMILES

[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[C@H:17]([NH:18][C:19](=[O:43])[CH:20]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:21]([O:23]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:22])[C:16](=[O:44])[N:10]2[C:11]=1[P:12]([OH:15])(=[O:14])[OH:13])(=[O:3])[CH3:2].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O.O.C([O-])(O)=O.[Na+:65]>C(Cl)Cl>[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[C@H:17]([NH:18][C:19](=[O:43])[CH:20]([C:21]([OH:23])=[O:22])[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:16](=[O:44])[N:10]2[C:11]=1[P:12]([O-:15])(=[O:13])[O-:14])(=[O:3])[CH3:2].[Na+:65].[Na+:65].[Na+:65]