Hydrochloric Acid → HCID 22874918, compound

HRID 265903Notes

Reaction equation

HRID 265903 reaction equation
C(OC([NH:8][C@@H:9]([CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]2[CH2:31][NH:30][CH2:29][CH2:28][N:27]2[C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])=[CH:22][CH:21]=1)[C:10]([O:12]C(C)(C)C)=[O:11])=O)(C)(C)C.Cl>CCOC(C)=O>[NH2:8][C@@H:9]([CH2:17][CH2:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([CH:26]2[CH2:31][NH:30][CH2:29][CH2:28][N:27]2[C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])=[CH:24][CH:25]=1)[C:10]([OH:12])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22874944HCID 22874944, compound

Product 1

HCID 22874918HCID 22874918, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 28-4 (1.0 g, 1.8 mmol) in 10 mL EtOAc was cooled to -40° C. and saturated with HCl gas. The solution was warmed to 0° C., then concentrated to give 28-5 as a tan solid. Rf (10:1:1 EtOH/H2O/NH4OH) 0.18.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-0ef3827d138f494988cde2585f6d80dc
Source dataset
uspto-grants-1997_07
Patent number
US05648368

Reaction notes

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