反应详情

温度

-15 °C

Dimethylformamide (1.6 g, 22 mmol) and 10 ml of tetrahydrofuran were mixed, to which 3.06 g (24 mmol) of oxalyl chloride were added dropwise under ice-cooling. After completion of the dropwise addition, the resulting mixture was stirred for further 10 minutes and was then cooled to -15° C. To the mixture so obtained, were added 2.0 g (10 mmol) of (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid and 10 ml of tetrahydrofuran, followed by stirring for 80 minutes. The reaction mixture was concentrated under reduced pressure. Slurry was collected by filtration under a nitrogen gas stream and then dried at room temperature, whereby 1.32 g of the title compound were obtained (yield: 43%).

1. additionwere added dropwise under ice-
2. temperaturecooling
3. additionAfter completion of the dropwise addition
4. customTo the mixture so obtained
5. stirringby stirring for 80 minutes
6. concentrationThe reaction mixture was concentrated under reduced pressure
7. filtrationSlurry was collected by filtration under a nitrogen gas stream
8. customdried at room temperature