Cyclohexane → HCID 70085481, compound

HRID 266455Notes

Reaction equation

HRID 266455 reaction equation
[SH:1][C:2]1[S:6][C:5]([S:7][CH2:8][N:9]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[S:10]2(=[O:12])=[O:11])=[N:4][N:3]=1.Cl.Cl[CH2:23][CH2:24][N:25]([CH2:28][CH3:29])[CH2:26][CH3:27].C(N(CC)CC)C.C1CCCCC1>CN(C=O)C.C(OCC)(=O)C>[CH2:24]([N:25]([CH2:28][CH3:29])[CH2:26][CH2:27][S:1][C:2]1[S:6][C:5]([S:7][CH2:8][N:9]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[S:10]2(=[O:12])=[O:11])=[N:4][N:3]=1)[CH3:23]

Participants

7

Reactant 4

HCID 8078CyclohexaneHCID 8471TriethylamineHCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 178515057HCID 178515057, compound

Product 1

HCID 70085481HCID 70085481, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

Following a procedure similar to that described in Example 33A, 2-(5-mercapto-1,3,4-thiadiazol-2-ylthiomethyl)saccharin is reacted with 2-chloroethyldiethylamine hydrochloride in DMF in the presence of triethylamine to give 2-(5-[2-(diethylamino)ethylthio]-1,3,4-thiadiazol-2-ylthiomethyl)saccharin, mp 93.0°-94.5° C. (from cyclohexane:ethyl acetate).

Sources & evidence

ORD record
ord-bcac902a6a644a2d9333eeccf811f580
Source dataset
uspto-grants-1997_07
Patent number
US05650422

Reaction notes

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