反应详情

To a suspension of 2.3 g. of 4-hydroxy-3-acetylbenzoic acid in 100 ml. of methylene chloride and 100 ml. of tetrahydrofuran, a mixture of 1.5 g. of triethylamine, 1.6 g. of 4-N-dimethylaminopyridine and 1.5 g. of acetic anhydride is added. The reaction mixture is heated at 50° for one hour. The solution is extracted with ethyl acetate, the organic layer washed with water and dilute hydrochloric acid and evaporated to dryness to yield 2.1 g. of the benzoic acid product. NMR in CDCl3

1. additionTo a suspension of 2.3 g
2. temperatureThe reaction mixture is heated at 50° for one hour
3. extractionThe solution is extracted with ethyl acetate
4. washthe organic layer washed with water and dilute hydrochloric acid
5. customevaporated to dryness
6. customto yield 2.1 g