Ammonium Hydroxide → HCID 178492120, compound

HRID 268257Notes

Reaction equation

HRID 268257 reaction equation
Cl.[NH:2]([C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]3[N:21]=[CH:20][NH:19][C:17]3=2)[N:12]=[C:11]([CH3:22])[CH:10]=1)C1C=CC=CC=1.N[C:24]1[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[N:28][CH:29]=1.[NH4+].[OH-]>CN(C)C=O>[CH3:31][O:30][C:27]1[N:28]=[CH:29][C:24]([NH:2][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]4[N:21]=[CH:20][NH:19][C:17]4=3)[N:12]=[C:11]([CH3:22])[CH:10]=2)=[CH:25][CH:26]=1

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 811216-Methoxy-3-pyridinylamineHCID 178428198HCID 178428198, compound

Product 1

HCID 178492120HCID 178492120, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A stirred mixture of the compound of Example I, C. (22 g. 0.1 mole) and 5-amino-2-methoxypyridine (12 g., 0.1 mole) in 200 ml. of dimethylformamide, was refluxed for 6 hours. The reaction mixture, after standing at room temperature overnight, was filtered to give a tan solid. The solid was treated with dilute NH4OH and then filtered to yield 30 g. (98%) of tan product.

Workup

  1. filtrationwas filtered
  2. customto give a tan solid
  3. filtrationfiltered
  4. customto yield 30 g

Sources & evidence

ORD record
ord-1d4c55da8e854349bce9030bd093ac33
Source dataset
uspto-grants-1976_03
Patent number
US03947434

Reaction notes

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