4-Methoxybenzylamine → HCID 178490943, compound

HRID 268272Notes

Reaction equation

HRID 268272 reaction equation
[ClH:1].[NH:2]([C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]3[N:21]=[CH:20][NH:19][C:17]3=2)[N:12]=[C:11]([CH3:22])[CH:10]=1)C1C=CC=CC=1.[CH3:23][O:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29]N)=[CH:27][CH:26]=1>CN(C)C=O>[OH2:24].[ClH:1].[CH3:23][O:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][NH:2][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]4[N:21]=[CH:20][NH:19][C:17]4=3)[N:12]=[C:11]([CH3:22])[CH:10]=2)=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 754524-MethoxybenzylamineHCID 178428198HCID 178428198, compound

Product 1

HCID 178490943HCID 178490943, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A stirred mixture of the compound of Example I, C. (22 g. 0.1 mole) and p-methoxy-benzylamine (14 g. 0.1 mole) in 200 ml. of dimethylformamide was refluxed for 6 hours. The reaction solution was stripped in vacuo to give 35 g. (98%) of pale yellow solid. Recrystallization from CH3OH/ether gave m.p. 250°-255°C.

Workup

  1. customto give 35 g
  2. customRecrystallization from CH3OH/ether
  3. customgave m.p. 250°-255°C.

Sources & evidence

ORD record
ord-2937d86850b44752bffcc0c2cc930f2c
Source dataset
uspto-grants-1976_03
Patent number
US03947434

Reaction notes

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