huagongshe.com
HRID269023

反应详情

EQUATION

反应方程式

HRID 269023 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：C[Si](C)(C)C#Cc1cnc2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)cn12
HCID86608010

8-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-3-trimethylsilanylethynyl-imidazo[1,2-a]pyridine

C20H16F6N2Si

PRODUCTS

生成物

1
结构：C#Cc1cnc2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)cn12
HCID86608011

3-Ethynyl-8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine

C17H8F6N2

收率 66%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CO
溶剂HCID887

Methanol

CH4O

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：COC(C)(C)C
溶剂HCID15413

Methyl tert-butyl ether

C5H12O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

To a solution of 8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-3-trimethylsilanylethynyl-imidazo[1,2-a]pyridine (10.5 g, 25 mmol) in THF (100 mL) and MeOH (250 mL) at 0° C. was added K2CO3 (340 mg, 10 mol %) and the mixture was stirred at 0° C. for 6 h. Diluted with TBME and ice water, separated, washed with brine, dried over Na2SO4, totally evaporated. Purified by column chromatography (heptane/AcOEt) and trituration with heptane and filtration gave the product as an off-white solid (5.8 g, 66%). MS (ISP) 355.0 [(M+H)+].

WORKUP

后处理

  1. customseparated
  2. washwashed with brine
  3. dry with materialdried over Na2SO4
  4. customtotally evaporated
  5. filtrationPurified by column chromatography (heptane/AcOEt) and trituration with heptane and filtration