反应详情

温度

2.5 °C

1-Amino-8-hydroxynaphthalene-3,6-disulfonic acid (72% strength, 44.4 g, 0.1 mol) was stirred in a mixture of water (340 mls) and 48% hydrobromic acid (20 mls). The suspension was cooled to 0-5° C. and sodium nitrite (7.6 g, 0.11 mol) was added in small portions. The mixture was stirred for 2 hours at 0-5° C. and then the excess nitrous acid was destroyed by the addition of sulfamic acid solution. Further 48% hydrobromic acid (70 mls) was added and the mixture cooled to 5° C. A solution of copper (I) bromide (14.4 g, 0.1 mol) in 48% hydrobromic acid (30 mls) and water (20 mls) was then added dropwise at 0-5° C. The mixture was stirred for 10 minutes at 5° C. and then the temperature was slowly raised to and maintained at 90° C. for 1 hour. The reaction mixture was cooled to room temperature and sodium chloride added (30% w/v). The product was collected by filtration and washed with 20% sodium chloride solution. The dried product (56 g) contained 49% sodium chloride. Yield 74%.

1. customthe excess nitrous acid was destroyed by the addition of sulfamic acid solution
2. additionFurther 48% hydrobromic acid (70 mls) was added
3. temperaturethe mixture cooled to 5° C
4. stirringThe mixture was stirred for 10 minutes at 5° C.
5. temperaturethe temperature was slowly raised to and
6. temperaturemaintained at 90° C. for 1 hour
7. temperatureThe reaction mixture was cooled to room temperature
8. filtrationThe product was collected by filtration
9. washwashed with 20% sodium chloride solution