Methyl iodide → HCID 23071583, compound

HRID 269802Notes

Reaction equation

HRID 269802 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1)([O-])=O.[H-].[Na+].[CH3:21]I>CN(C=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH3:21])[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 332214N-(4-nitrophenyl)morpholine-4-carboxamide

Product 1

HCID 23071583HCID 23071583, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

N-methylation of N-(4-nitrophenyl)morpholine-4-carboxamide was effected by allowing it to react with sodium hydride and methyl iodide in DMF, and the resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain N-(4-aminophenyl)-N-methylmorpholine-4-carboxamide. F: 236.

Sources & evidence

ORD record
ord-6aec195e3c744350a6d739f69e0dabd2
Source dataset
uspto-grants-2008_11
Patent number
US07449456B2

Reaction notes

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