Hydrochloric Acid → HCID 225741, compound

HRID 270239Notes

Reaction equation

HRID 270239 reaction equation
[Li+].[OH-].[Cl:3][C:4]([Cl:15])([Cl:14])[CH:5]=[CH:6][C:7]([O:9]CCCC)=[O:8].Cl>O.C1COCC1>[Cl:3][C:4]([Cl:15])([Cl:14])[CH:5]=[CH:6][C:7]([OH:9])=[O:8]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 54348800HCID 54348800, compound

Product 1

HCID 225741HCID 225741, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

17.82 g of LiOH in 20 ml of water are added to a solution containing 3 g of butyl 4,4,4-trichloro-but-2-enoate (0.0128 moles) in 300 ml of THF. The mixture is stirred for 1 hour at room temperature. It is then brought to neutral pH with the addition of HCl 1N, extracted with ethyl acetate and anhydrified on Na2SO4. The solid obtained after evaporation of the solvent at reduced pressure and washing with petroleum ether weighs 2.1 g (87% yield).

Workup

  1. extractionextracted with ethyl acetate
  2. customThe solid obtained
  3. customafter evaporation of the solvent at reduced pressure
  4. washwashing with petroleum ether

Sources & evidence

ORD record
ord-7f1d9e0f48b043fc8bcdb7161e9a8e56
Source dataset
uspto-grants-2008_11
Patent number
US07449528B2

Reaction notes

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