Triethylamine → HCID 11648702, compound
Reaction equation
[F:1][C:2]([F:7])([F:6])[C:3](O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.[CH:22]([C@:25]1([C:31]([N:33]2[CH2:38][CH2:37][N:36]([C:39]3[CH:40]=[N:41][CH:42]=C(C(F)(F)F)[CH:44]=3)[CH2:35][CH2:34]2)=[O:32])[CH2:29][CH2:28][C@@H:27]([NH2:30])[CH2:26]1)([CH3:24])[CH3:23].[CH3:49][CH:50]1[C:55](=O)[CH2:54][CH2:53][O:52][CH2:51]1.C(N(CC)CC)C.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(Cl)Cl.CCOC(C)=O>[CH:22]([C@:25]1([C:31]([N:33]2[CH2:34][CH2:35][N:36]([C:39]3[CH:40]=[N:41][CH:42]=[C:3]([C:2]([F:7])([F:6])[F:1])[CH:44]=3)[CH2:37][CH2:38]2)=[O:32])[CH2:29][CH2:28][C@@H:27]([NH:30][CH:55]2[CH2:54][CH2:53][O:52][CH2:51][CH:50]2[CH3:49])[CH2:26]1)([CH3:24])[CH3:23]Participants
Procedure
To a solution of (1R,3S)-3-isopropyl-3-({4-[5-(trifluoromethyl)pyridin-3-yl]piperazin-1-yl}carbonyl)cyclopentanamine tris(trifluoroacetate) (25 mg, 0.034 mmol), 3-methyltetrahydro-4H-pyran-4-one (11 mg, 0.10 mmol) and triethylamine (0.024 mL, 0.17 mmol) in methylene chloride (2 mL) was added sodium triacetoxyborohydride (22 mg, 0.10 mmol). The mixture was stirred under N2 at room temperature overnight and diluted with EtOAc. The resulting solution was washed with saturated NaHCO3, dried (MgSO4), and concentrated. The residue was purified by flash chromatography on silica gel (EtOAc to EtOAc/MeOH/Et3N=9:1:0.5) to give 14 mg of desired product as a mixture of two isomers. The two isomers were separated by chiral HPLC to give peak 1 and peak 2. MS calculated for C25H37F3N4O2: (M+H) 483; found 483.2.
Workup
- washThe resulting solution was washed with saturated NaHCO3
- dry with materialdried (MgSO4)
- concentrationconcentrated
- customThe residue was purified by flash chromatography on silica gel (EtOAc to EtOAc/MeOH/Et3N=9:1:0.5)
Sources & evidence
- ORD record
- ord-a63eca6f2b07412c95a189aa4fc8cda5
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07449467B2
Reaction notes
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