Dimethylformamide → HCID 21071039, compound

HRID 270903Notes

Reaction equation

HRID 270903 reaction equation
[CH:1]([C:4]1[C:8]([Cl:9])=[C:7]([CH:10]([CH3:12])[CH3:11])[NH:6][N:5]=1)([CH3:3])[CH3:2].C([O-])([O-])=O.[K+].[K+].Cl[CH2:20][C:21]([N:23]1[CH2:28][CH2:27][N:26]([C:29]2[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=2)[CH2:25][CH2:24]1)=[O:22].CN(C=O)C>CCCCCC.C(OCC)(=O)C>[CH:10]([C:7]1[C:8]([Cl:9])=[C:4]([CH:1]([CH3:3])[CH3:2])[N:5]([CH2:20][C:21]([N:23]2[CH2:24][CH2:25][N:26]([C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)[CH2:27][CH2:28]2)=[O:22])[N:6]=1)([CH3:12])[CH3:11]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 18485111-(Chloroacetyl)-4-(4-fluorophenyl)piperazineHCID 21071132HCID 21071132, compound

Product 1

HCID 21071039HCID 21071039, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Protocol T was followed using 3,5-Diisopropyl-4-chloro-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1, Rf=0.76) afforded the title compound as white solid. MS (ES) M+H) expected=406.9, found 407.1.

Sources & evidence

ORD record
ord-a8528cc28cc94323ab3c1506d36fd338
Source dataset
uspto-grants-2008_11
Patent number
US07449576B1

Reaction notes

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