反应详情

A solution of 4-phenylpiperidine (1.0 g, 6.2 mmol) was dissolved in THF (20 mL) and treated with formaldehyde (2.6 mL of a 37% solution in water). To the stirred reaction mixture was added sodium triacetoxyborohydride (2.63 g, 12.4 mmol). The reaction mixture was maintained at room temperature for 1 h, and then concentrated in vacuo. The residue was dissolved in dichloromethane, washed with 5% aqueous NaHCO3 and brine, then dried over MgSO4. Evaporation of the solvent yielded 1-methyl-4-phenylpiperidine 113 (1.06 g, 97%) as a colorless oil.

1. customTo the stirred reaction mixture
2. concentrationconcentrated in vacuo
3. dissolutionThe residue was dissolved in dichloromethane
4. washwashed with 5% aqueous NaHCO3 and brine
5. dry with materialdried over MgSO4
6. customEvaporation of the solvent