Water → 1-Methyl 2,6-dichloro-1,4-benzenedicarboxylate

HRID 271322Notes

Reaction equation

HRID 271322 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([C:11]([O:13]C)=[O:12])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+].O.O1CCC[CH2:20]1>Cl.C(OCC)(=O)C>[CH3:20][O:6][C:4](=[O:5])[C:3]1[C:2]([Cl:1])=[CH:10][C:9]([C:11]([OH:13])=[O:12])=[CH:8][C:7]=1[Cl:15]

Participants

7

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 684593252,6-Dichloro-4-(methoxycarbonyl)benzoic acid

Product 1

HCID 186730161-Methyl 2,6-dichloro-1,4-benzenedicarboxylate

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

The mixture of 560 mg of 2,6-dichloro-4-methoxycarbonyl benzoic acid, 85 mg of sodium hydroxide, 5 ml of water and 5 ml of tetrahydrofuran was stirred for 1 hour. The mixture was diluted with 1N hydrochloric acid and treated by an ordinary method using ethyl acetate as an extractant to obtain the title compound.

Workup

  1. additiontreated by an ordinary method

Sources & evidence

ORD record
ord-215d26ea76dd40ef810298548e933336
Source dataset
uspto-grants-2008_11
Patent number
US07452905B2

Reaction notes

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