Diethyl Oxalate → HCID 59836313, compound

HRID 271842Notes

Reaction equation

HRID 271842 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][C:8](=[O:11])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[Li+].C[Si]([N-][Si](C)(C)C)(C)C.[CH2:22]([O:24][C:25](=[O:31])[C:26](OCC)=[O:27])[CH3:23]>CCOCC>[CH2:22]([O:24][C:25](=[O:31])[C:26](=[O:27])[CH:9]1[C:8](=[O:11])[CH2:7][CH2:6][C:5]2([O:4][CH2:3][CH2:2][O:1]2)[CH2:10]1)[CH3:23]

Participants

5

Reactant 3

HCID 7268Diethyl OxalateHCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 2733832Lithium Hexamethyldisilazide

Product 1

HCID 59836313HCID 59836313, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

According to the procedure of Example 2, a solution of 1,4-dioxaspiro[4.5]decane-8-one Compound 22a in ether was added to a solution of LHMDS in ether at −78° C. The diethyloxalate Compound 2b was added to the mixture and reacted to produce an oxo-(8-oxo-1,4-dioxa-spiro[4.5]dec-7-yl)-acetic acid ethyl ester Compound 22b.

Workup

  1. customreacted

Sources & evidence

ORD record
ord-333723045d2b47c6adc401a9ef4f32e5
Source dataset
uspto-grants-2008_11
Patent number
US07452997B2

Reaction notes

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