反应详情

Piperazine-1-carboxylic acid ethyl ester (3.0 g, 18.9 mmol), K2CO3 (2.8 g, 1.1 eq.), DMF (30 ml, 10 vol) and 1-bromo-3-chloropropane (1.8 ml, 18.9 mmol, 1 eq.) were reacted together at room temperature overnight. The reaction was quenched with water (100 ml) and extracted with DCM (3×50 ml). The combined DCM extracts were dried over MgSO4, filtered washed with DCM and concentrated in vacuo to give the title compound (3.1 g, 70%) as a pale yellow oil.

1. customThe reaction was quenched with water (100 ml)
2. extractionextracted with DCM (3×50 ml)
3. dry with materialThe combined DCM extracts were dried over MgSO4
4. filtrationfiltered
5. washwashed with DCM
6. concentrationconcentrated in vacuo