反应详情

A mixture of (1-benzhydrylazetidin-3-yl)methanol (4.0 g, 15.8 mmol), acetone (20 ml), 2-propanol (80 ml), c.HCl (1.5 ml) and Pd(OH)2 was hydrogenated at 50 psi/50° for 18 hours. The reaction mixture was filtered through Arbocel® and concentrated in vacuo, the residue was triturated with diisopropyl ether (50 ml) to give the title compound as a pale green hygroscopic powder (2.6 g, 99%). LRMS ESI+m/z 130 [M+H]+.

1. filtrationThe reaction mixture was filtered through Arbocel®
2. concentrationconcentrated in vacuo
3. customthe residue was triturated with diisopropyl ether (50 ml)