反应详情

To a solution of methyl 3-(4-hydroxyphenyl)propanoate (0.3 g, 1.67 mmol) in N,N-dimethylformamide (4.0 mL) was added 60% sodium hydride (0.073 g, 1.83 mmol) at 0° C. with stirring, and the mixture was stirred at the same temperature for 15 min. Then, 3-bromobenzylbromide (0.44 g, 1.75 mmol) was added to the mixture at 0° C. with stirring, and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was diluted with ethyl acetate and washed with 5% aqueous potassium hydrogensulfate solution and saturated brine. The ethyl acetate layer was dried over magnesium sulfate and concentrated under reduced pressure to give the title compound (0.84 g, yield 72%) as a colorless powder.

1. stirringthe mixture was stirred at the same temperature for 15 min
2. stirringwith stirring
3. stirringthe mixture was stirred at room temperature for 2 hrs
4. washwashed with 5% aqueous potassium hydrogensulfate solution and saturated brine
5. dry with materialThe ethyl acetate layer was dried over magnesium sulfate
6. concentrationconcentrated under reduced pressure